Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness

OBJECTIVE—: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving mitochondrial respiration affects plaque burden...

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Dettagli Bibliografici
Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Yu, Emma P.K., Reinhold, Johannes, Yu, Haixiang, Starks, Lakshi, Uryga, Anna K., Foote, Kirsty, Finigan, Alison, Figg, Nichola, Pung, Yuh-Fen, Logan, Angela, Murphy, Michael P., Bennett, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2017
Soggetti:
Translational Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701734/
https://ncbi.nlm.nih.gov/pubmed/28970293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310042
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