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mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus
PURPOSE: This study aimed to develop a novel methoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA)/D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) mixed micelle drug delivery system to improve lamotrigine (LTG) distribution in the hippocampus. METHODS: LTG-loaded mPEG-PLA/TPGS mixed micell...
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| Publicado no: | Int J Nanomedicine |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5701607/ https://ncbi.nlm.nih.gov/pubmed/29200847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S145488 |
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