mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus

PURPOSE: This study aimed to develop a novel methoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA)/D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) mixed micelle drug delivery system to improve lamotrigine (LTG) distribution in the hippocampus. METHODS: LTG-loaded mPEG-PLA/TPGS mixed micell...

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Dettagli Bibliografici
Pubblicato in:Int J Nanomedicine
Autori principali: Yu, Anan, Lv, Jieqiong, Yuan, Fang, Xia, Zihua, Fan, Kaiyan, Chen, Gang, Ren, Jialin, Lin, Cuicui, Wei, Shijie, Yang, Fan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701607/
https://ncbi.nlm.nih.gov/pubmed/29200847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S145488
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