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Development and evaluation of mPEG-PLLA polymeric micelles encapsulating enrofloxacin for enhanced solubility, bioavailability, and antibacterial performance

The aim of this study was to prepare polymeric micelles composed of enrofloxacin (ENR) and methoxy poly (ethylene glycol)-poly(lactide) (mPEG-PLLA) using a solvent evaporation method to overcome the solubility-limited oral bioavailability of ENR. The formulation was optimized using a Box–Behnken des...

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Autori principali: Yanling Sun, Yanan Mao, Xin He, Xinghua Zhao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-07-01
Serie:Frontiers in Veterinary Science
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Accesso online:https://www.frontiersin.org/articles/10.3389/fvets.2025.1595137/full
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