TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche

Hematopoietic stem and progenitor cells (HSPCs) reside in the supportive stromal niche in bone marrow (BM); when needed, however, they are rapidly mobilized into the circulation, suggesting that HSPCs are intrinsically highly motile but usually stay in the niche. We questioned what determines the mo...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood
मुख्य लेखकों: Yahata, Takashi, Ibrahim, Abd Aziz, Muguruma, Yukari, Eren, Mesut, Shaffer, Alexander M., Watanabe, Nobuo, Kaneko, Satoko, Nakabayashi, Tetsuo, Dan, Takashi, Hirayama, Noriaki, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2017
विषय:
Hematopoiesis and Stem Cells
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701521/
https://ncbi.nlm.nih.gov/pubmed/28821477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-767384
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