A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence

Doxorubicin, an anthracycline antibiotic, is a commonly used anticancer drug. In spite of its widespread usage, its therapeutic effect is limited by its cardiotoxicity. On the cellular level, Doxorubicin-induced cardiotoxicity manifests as stress induced premature senescence. Previously, we demonstr...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Ghosh, Asish K., Rai, Rahul, Park, Kitae E., Eren, Mesut, Miyata, Toshio, Wilsbacher, Lisa D., Vaughan, Douglas E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341920/
https://ncbi.nlm.nih.gov/pubmed/27736799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12494
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