The PAI-1 Antagonist TM5441 Attenuates L-NAME-Induced Hypertension and Vascular Senescence

BACKGROUND: Long-term inhibition of nitric oxide synthase (NOS) by L-arginine analogues such as N(ω)-nitro-L-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo. We previously reported that PAI-1-deficient mice (PAI-1(−/−...

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Autori principali: Boe, Amanda E., Eren, Mesut, Murphy, Sheila B., Kamide, Christine E., Ichimura, Atsuhiko, Terry, David, McAnally, Danielle, Smith, Layton H., Miyata, Toshio, Vaughan, Douglas E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933362/
https://ncbi.nlm.nih.gov/pubmed/24092817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.003192
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