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PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice

Cellular senescence restricts the proliferative capacity of cells and is accompanied by the production of several proteins, collectively termed the “senescence-messaging secretome” (SMS). As senescent cells accumulate in tissue, local effects of the SMS have been hypothesized to disrupt tissue regen...

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Detalhes bibliográficos
Main Authors: Eren, Mesut, Boe, Amanda E., Murphy, Sheila B., Place, Aaron T., Nagpal, Varun, Morales-Nebreda, Luisa, Urich, Daniela, Quaggin, Susan E., Budinger, G. R. Scott, Mutlu, Gökhan M., Miyata, Toshio, Vaughan, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024885/
https://ncbi.nlm.nih.gov/pubmed/24778222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321942111
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