Nitric Oxide Prevents Alveolar Senescence and Emphysema in a Mouse Model

N(ω)-nitro-L-arginine methyl ester (L-NAME) treatment induces arteriosclerosis and vascular senescence. Here, we report that the systemic inhibition of nitric oxide (NO) production by L-NAME causes pulmonary emphysema. L-NAME-treated lungs exhibited both the structural (alveolar tissue destruction)...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Boe, Amanda E., Eren, Mesut, Morales-Nebreda, Luisa, Murphy, Sheila B., Budinger, G. R. Scott, Mutlu, Gökhan M., Miyata, Toshio, Vaughan, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355068/
https://ncbi.nlm.nih.gov/pubmed/25756287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116504
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