PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice

Cellular senescence restricts the proliferative capacity of cells and is accompanied by the production of several proteins, collectively termed the “senescence-messaging secretome” (SMS). As senescent cells accumulate in tissue, local effects of the SMS have been hypothesized to disrupt tissue regen...

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Hlavní autoři: Eren, Mesut, Boe, Amanda E., Murphy, Sheila B., Place, Aaron T., Nagpal, Varun, Morales-Nebreda, Luisa, Urich, Daniela, Quaggin, Susan E., Budinger, G. R. Scott, Mutlu, Gökhan M., Miyata, Toshio, Vaughan, Douglas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024885/
https://ncbi.nlm.nih.gov/pubmed/24778222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321942111
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