TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche

Hematopoietic stem and progenitor cells (HSPCs) reside in the supportive stromal niche in bone marrow (BM); when needed, however, they are rapidly mobilized into the circulation, suggesting that HSPCs are intrinsically highly motile but usually stay in the niche. We questioned what determines the mo...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Yahata, Takashi, Ibrahim, Abd Aziz, Muguruma, Yukari, Eren, Mesut, Shaffer, Alexander M., Watanabe, Nobuo, Kaneko, Satoko, Nakabayashi, Tetsuo, Dan, Takashi, Hirayama, Noriaki, Vaughan, Douglas E., Miyata, Toshio, Ando, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701521/
https://ncbi.nlm.nih.gov/pubmed/28821477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-767384
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