Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can also develop, resulting in relapse. Here we report a mechanism by which extrinsic resistance develops after local ablative radiation that reli...

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Udgivet i:Nat Commun
Main Authors: Liang, Hua, Deng, Liufu, Hou, Yuzhu, Meng, Xiangjiao, Huang, Xiaona, Rao, Enyu, Zheng, Wenxin, Mauceri, Helena, Mack, Matthias, Xu, Meng, Fu, Yang-Xin, Weichselbaum, Ralph R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701019/
https://ncbi.nlm.nih.gov/pubmed/29170400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01566-5
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