STING-dependent Cytosolic DNA Sensing Promotes Radiation-induced Type I interferon-dependent Antitumor Immunity in Immunogenic Tumors

Ionizing radiation-mediated tumor regression depends on type I interferon (IFN) and the adaptive immune response, but the several pathways control I IFN induction. Here, we demonstrate that adaptor protein STING, but not MyD88, is required for type I IFN-dependent antitumor effects of radiation. In...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Deng, Liufu, Liang, Hua, Xu, Meng, Yang, Xuanming, Burnette, Byron, Arina, Ainhoa, Li, Xiao-Dong, Mauceri, Helenna, Beckett, Michael, Darga, Thomas, Huang, Xiaona, Gajewski, Thomas F., Chen, Zhijian J., Fu, Yang-Xin, Weichselbaum, Ralph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155593/
https://ncbi.nlm.nih.gov/pubmed/25517616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.10.019
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