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Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Cancer cachexia is a devastating metabolic syndrome characterized by systemic inflammation and massive muscle and adipose tissue wasting. Although it is responsible for approximately one-third of cancer deaths, no effective therapies are available and the underlying mechanisms have not been fully el...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5700099/ https://ncbi.nlm.nih.gov/pubmed/29167426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01645-7 |
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