Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Cancer cachexia is a devastating metabolic syndrome characterized by systemic inflammation and massive muscle and adipose tissue wasting. Although it is responsible for approximately one-third of cancer deaths, no effective therapies are available and the underlying mechanisms have not been fully el...

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Publicado en:Nat Commun
Autores principales: Segatto, Marco, Fittipaldi, Raffaella, Pin, Fabrizio, Sartori, Roberta, Dae Ko, Kyung, Zare, Hossein, Fenizia, Claudio, Zanchettin, Gianpietro, Pierobon, Elisa Sefora, Hatakeyama, Shinji, Sperti, Cosimo, Merigliano, Stefano, Sandri, Marco, Filippakopoulos, Panagis, Costelli, Paola, Sartorelli, Vittorio, Caretti, Giuseppina
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700099/
https://ncbi.nlm.nih.gov/pubmed/29167426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01645-7
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