Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis

Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression in response to DNA damage. Despite its essential function, CHK1 has been identified as a target to kill cancer cells and studies using Chk1 haploinsufficient mice initially suggested a...

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Udgivet i:Nat Commun
Main Authors: Schuler, Fabian, Weiss, Johannes G., Lindner, Silke E., Lohmüller, Michael, Herzog, Sebastian, Spiegl, Simon F., Menke, Philipp, Geley, Stephan, Labi, Verena, Villunger, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700047/
https://ncbi.nlm.nih.gov/pubmed/29167438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01850-4
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