The Blood Pressure–Lowering Effect of 20-HETE Blockade in Cyp4a14(−/−) Mice Is Associated with Natriuresis

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) has been linked to pro-hypertensive and anti-hypertensive actions through its ability to promote vasoconstriction and inhibit Na transport in the ascending limb of the loop of Henle, respectively. In this study, we assessed the effects of 20-HETE...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Pandey, Varunkumar, Garcia, Victor, Gilani, Ankit, Mishra, Priyanka, Zhang, Frank Fan, Paudyal, Mahesh P., Falck, John R., Nasjletti, Alberto, Wang, Wen-Hui, Schwartzman, Michal Laniado
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2017
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698946/
https://ncbi.nlm.nih.gov/pubmed/28912346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243618
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