The Blood Pressure–Lowering Effect of 20-HETE Blockade in Cyp4a14(−/−) Mice Is Associated with Natriuresis

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) has been linked to pro-hypertensive and anti-hypertensive actions through its ability to promote vasoconstriction and inhibit Na transport in the ascending limb of the loop of Henle, respectively. In this study, we assessed the effects of 20-HETE...

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Dettagli Bibliografici
Pubblicato in:J Pharmacol Exp Ther
Autori principali: Pandey, Varunkumar, Garcia, Victor, Gilani, Ankit, Mishra, Priyanka, Zhang, Frank Fan, Paudyal, Mahesh P., Falck, John R., Nasjletti, Alberto, Wang, Wen-Hui, Schwartzman, Michal Laniado
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2017
Soggetti:
Cardiovascular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698946/
https://ncbi.nlm.nih.gov/pubmed/28912346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.243618
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