Proximal tubule-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice

20-Hydroxyeicosatetraenoic acid (20-HETE) has been linked to blood pressure (BP) regulation via actions on the renal microvasculature and tubules. We assessed the tubular 20-HETE contribution to hypertension by generating transgenic mice overexpressing the CYP4A12-20-HETE synthase (PT-4a12 mice) und...

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Publicat a:Am J Physiol Regul Integr Comp Physiol
Autors principals: Gilani, Ankit, Agostinucci, Kevin, Pascale, Jonathan V., Hossain, Sakib, Kandhi, Sharath, Pandey, Varunkumar, Garcia, Victor, Nasjletti, Alberto, Laniado Schwartzman, Michal
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2020
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468799/
https://ncbi.nlm.nih.gov/pubmed/32633545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00089.2020
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