Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE

We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), results in endothelial dysfunction and hypertension in Sprague-Dawley (SD) rats (Wang JS, Singh H, Zhang F, Ishizuka T, Deng H, Kem...

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Auteurs principaux: Inoue, Kazuyoshi, Sodhi, Komal, Puri, Nitin, Gotlinger, Katherine H., Cao, Jiang, Rezzani, Rita, Falck, John R., Abraham, Nader G., Laniado-Schwartzman, Michal
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2009
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775578/
https://ncbi.nlm.nih.gov/pubmed/19675180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00364.2009
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