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Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP) 4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), results in endothelial dysfunction and hypertension in Sprague-Dawley (SD) rats (Wang JS, Singh H, Zhang F, Ishizuka T, Deng H, Kem...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2775578/ https://ncbi.nlm.nih.gov/pubmed/19675180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00364.2009 |
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