Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

A four‐membered oxygen ring (oxetane) can be readily grafted into native peptides and proteins through site‐selective bis‐alkylation of cysteine residues present as disulfides under mild and biocompatible conditions. The selective installation of the oxetane graft enhances stability and activity, as...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Martínez‐Sáez, Nuria, Sun, Shuang, Oldrini, Davide, Sormanni, Pietro, Boutureira, Omar, Carboni, Filippo, Compañón, Ismael, Deery, Michael J., Vendruscolo, Michele, Corzana, Francisco, Adamo, Roberto, Bernardes, Gonçalo J. L.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698723/
https://ncbi.nlm.nih.gov/pubmed/28968001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201708847
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars