Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

A four‐membered oxygen ring (oxetane) can be readily grafted into native peptides and proteins through site‐selective bis‐alkylation of cysteine residues present as disulfides under mild and biocompatible conditions. The selective installation of the oxetane graft enhances stability and activity, as...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Martínez‐Sáez, Nuria, Sun, Shuang, Oldrini, Davide, Sormanni, Pietro, Boutureira, Omar, Carboni, Filippo, Compañón, Ismael, Deery, Michael J., Vendruscolo, Michele, Corzana, Francisco, Adamo, Roberto, Bernardes, Gonçalo J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698723/
https://ncbi.nlm.nih.gov/pubmed/28968001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201708847
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