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Site‐Selective Modification of Proteins with Oxetanes
Oxetanes are four‐membered ring oxygen heterocycles that are advantageously used in medicinal chemistry as modulators of physicochemical properties of small molecules. Herein, we present a simple method for the incorporation of oxetanes into proteins through chemoselective alkylation of cysteine. We...
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| Veröffentlicht in: | Chemistry |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5434895/ https://ncbi.nlm.nih.gov/pubmed/28261889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201700745 |
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