Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine‐Selective Protein Modification and Charge Modulation

Quaternized vinyl‐ and alkynyl‐pyridine reagents were shown to react in an ultrafast and selective manner with several cysteine‐tagged proteins at near‐stoichiometric quantities. We have demonstrated that this method can effectively create a homogenous antibody–drug conjugate that features a precise...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Matos, Maria J., Navo, Claudio D., Hakala, Tuuli, Ferhati, Xhenti, Guerreiro, Ana, Hartmann, David, Bernardim, Barbara, Saar, Kadi L., Compañón, Ismael, Corzana, Francisco, Knowles, Tuomas P. J., Jiménez‐Osés, Gonzalo, Bernardes, Gonçalo J. L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618083/
https://ncbi.nlm.nih.gov/pubmed/30897271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201901405
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