Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting products that undergo thiol-exchange reactions in vivo. Here we present the rational design of carbonylacrylic reagents for chemoselective cystein...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Bernardim, Barbara, Cal, Pedro M.S.D., Matos, Maria J., Oliveira, Bruno L., Martínez-Sáez, Nuria, Albuquerque, Inês S., Perkins, Elizabeth, Corzana, Francisco, Burtoloso, Antonio C.B., Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095172/
https://ncbi.nlm.nih.gov/pubmed/27782215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13128
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