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Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents
Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting products that undergo thiol-exchange reactions in vivo. Here we present the rational design of carbonylacrylic reagents for chemoselective cystein...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5095172/ https://ncbi.nlm.nih.gov/pubmed/27782215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13128 |
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