Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents

Maleimides remain the reagents of choice for the preparation of therapeutic and imaging protein conjugates despite the known instability of the resulting products that undergo thiol-exchange reactions in vivo. Here we present the rational design of carbonylacrylic reagents for chemoselective cystein...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Bernardim, Barbara, Cal, Pedro M.S.D., Matos, Maria J., Oliveira, Bruno L., Martínez-Sáez, Nuria, Albuquerque, Inês S., Perkins, Elizabeth, Corzana, Francisco, Burtoloso, Antonio C.B., Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095172/
https://ncbi.nlm.nih.gov/pubmed/27782215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13128
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