Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice

The Na(+)‐taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids. However, plasma bile acid levels are normal in a subset of NTCP knockout mice and in mice treated with myrcludex B, a specific NTCP inhibitor. Here, we elucidated w...

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Publicado en:Hepatology
Autores principales: Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Katafuchi, Takeshi, Blank, Antje, Donkers, Joanne M., van Hoppe, Stéphanie, de Waart, Dirk. R., Tolenaars, Dagmar, van der Meer, Jonathan H.M., Wildenberg, Manon, Beuers, Ulrich, Oude Elferink, Ronald P.J., Schinkel, Alfred H., van de Graaf, Stan F.J.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698707/
https://ncbi.nlm.nih.gov/pubmed/28498614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29251
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