Loading...

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice

The Na(+)‐taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids. However, plasma bile acid levels are normal in a subset of NTCP knockout mice and in mice treated with myrcludex B, a specific NTCP inhibitor. Here, we elucidated w...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Hepatology
Main Authors: Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Katafuchi, Takeshi, Blank, Antje, Donkers, Joanne M., van Hoppe, Stéphanie, de Waart, Dirk. R., Tolenaars, Dagmar, van der Meer, Jonathan H.M., Wildenberg, Manon, Beuers, Ulrich, Oude Elferink, Ronald P.J., Schinkel, Alfred H., van de Graaf, Stan F.J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698707/
https://ncbi.nlm.nih.gov/pubmed/28498614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29251
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!