Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice

Active secretion of bile salts into the canalicular lumen drives bile formation and promotes biliary cholesterol and phospholipid output. Disrupting hepatic bile salt uptake, by inhibition of sodium‐taurocholate cotransporting polypetide (NTCP; Slc10a1) with Myrcludex B, is expected to limit bile sa...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Roscam Abbing, Reinout L.P., Slijepcevic, Davor, Donkers, Joanne M., Havinga, Rick, Duijst, Suzanne, Paulusma, Coen C., Kuiper, Johan, Kuipers, Folkert, Groen, Albert K., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003915/
https://ncbi.nlm.nih.gov/pubmed/31136002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30792
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