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Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice

Active secretion of bile salts into the canalicular lumen drives bile formation and promotes biliary cholesterol and phospholipid output. Disrupting hepatic bile salt uptake, by inhibition of sodium‐taurocholate cotransporting polypetide (NTCP; Slc10a1) with Myrcludex B, is expected to limit bile sa...

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Dettagli Bibliografici
Pubblicato in:Hepatology
Autori principali: Roscam Abbing, Reinout L.P., Slijepcevic, Davor, Donkers, Joanne M., Havinga, Rick, Duijst, Suzanne, Paulusma, Coen C., Kuiper, Johan, Kuipers, Folkert, Groen, Albert K., Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003915/
https://ncbi.nlm.nih.gov/pubmed/31136002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.30792
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