Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking all established and predicted mouse Oatp1a/1b tra...

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Detalhes bibliográficos
Main Authors: van de Steeg, Evita, Wagenaar, Els, van der Kruijssen, Cornelia M.M., Burggraaff, Johanna E.C., de Waart, Dirk R., Elferink, Ronald P.J. Oude, Kenworthy, Kathryn E., Schinkel, Alfred H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912192/
https://ncbi.nlm.nih.gov/pubmed/20644253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42168
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