Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications. To investigate the physiological and pharmacological roles of CYP3A, we generated Cyp3a-knockout (Cyp3a(–/–)) mice lacking all func...

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Hauptverfasser: van Herwaarden, Antonius E., Wagenaar, Els, van der Kruijssen, Cornelia M.M., van Waterschoot, Robert A.B., Smit, Johan W., Song, Ji-Ying, van der Valk, Martin A., van Tellingen, Olaf, van der Hoorn, José W.A., Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045619/
https://ncbi.nlm.nih.gov/pubmed/17975676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33435
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