P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin

Salinomycin is a polyether organic anion that is extensively used as a coccidiostatic antibiotic in poultry and commonly fed to ruminant animals to improve feed efficiency. However, salinomycin also causes severe toxicity when accidentally fed to animals in high doses. In addition, humans are highly...

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Detalhes bibliográficos
Main Authors: Lagas, Jurjen S., Sparidans, Rolf W., van Waterschoot, Robert A. B., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258498/
https://ncbi.nlm.nih.gov/pubmed/18195061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01041-07
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