P-Glycoprotein Limits Oral Availability, Brain Penetration, and Toxicity of an Anionic Drug, the Antibiotic Salinomycin

Salinomycin is a polyether organic anion that is extensively used as a coccidiostatic antibiotic in poultry and commonly fed to ruminant animals to improve feed efficiency. However, salinomycin also causes severe toxicity when accidentally fed to animals in high doses. In addition, humans are highly...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lagas, Jurjen S., Sparidans, Rolf W., van Waterschoot, Robert A. B., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258498/
https://ncbi.nlm.nih.gov/pubmed/18195061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01041-07
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky