The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. We show here that mice lacking Bcrp1/Abcg2 become extremely sensitive to the dietary chlorophyll-breakdown product pheophorbide a,...

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Bibliografiska uppgifter
Huvudupphovsmän: Jonker, Johan W., Buitelaar, Marije, Wagenaar, Els, van der Valk, Martin A., Scheffer, George L., Scheper, Rik J., Plösch, Torsten, Kuipers, Folkert, Elferink, Ronald P. J. Oude, Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC137771/
https://ncbi.nlm.nih.gov/pubmed/12429862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202607599
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