Comparing BMD‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay

There is growing interest in quantitative analysis of in vivo genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic rodent (TGR) assay variants, employing different rod...

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Vydáno v:Environ Mol Mutagen
Hlavní autoři: Wills, John W., Johnson, George E., Battaion, Hannah L., Slob, Wout, White, Paul A., Gollapudi, B.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698699/
https://ncbi.nlm.nih.gov/pubmed/28945287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22137
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