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Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

De novo mutations arise mostly in the male germline and may contribute to adverse health outcomes in subsequent generations. Traditional methods for assessing the induction of germ cell mutations require the use of large numbers of animals, making them impractical. As such, germ cell mutagenicity is...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: O'Brien, Jason M., Beal, Marc A., Gingerich, John D., Soper, Lynda, Douglas, George R., Yauk, Carole L., Marchetti, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692354/
https://ncbi.nlm.nih.gov/pubmed/25145276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/51576
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