Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis

Several Complement proteins exacerbate prion disease, including C3, C1q, and CD21/35. These proteins of the Complement cascade likely increase uptake, trafficking, and retention of prions in the lymphoreticular system, hallmark sites of early prion propagation. Complement regulatory protein Factor H...

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Publicado en:J Immunol
Autores principales: Kane, Sarah J, Farley, Taylor K, Gordon, Elizabeth O, Estep, Joshua, Bender, Heather R, Moreno, Julie A, Bartz, Jason, Telling, Glenn C, Pickering, Matthew C, Zabel, Mark D
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698161/
https://ncbi.nlm.nih.gov/pubmed/29070671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701100
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