Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination

The causative factors underlying conformational conversion of cellular prion protein (PrP(C)) into its infectious counterpart (PrP(Sc)) during prion infection remain undetermined, in part because of a lack of monoclonal antibodies (mAbs) that can distinguish these conformational isoforms. Here we sh...

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Foilsithe in:J Biol Chem
Main Authors: Kang, Hae-Eun, Bian, Jifeng, Kane, Sarah J., Kim, Sehun, Selwyn, Vanessa, Crowell, Jenna, Bartz, Jason C., Telling, Glenn C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383396/
https://ncbi.nlm.nih.gov/pubmed/32513872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012796
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