Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination

The causative factors underlying conformational conversion of cellular prion protein (PrP(C)) into its infectious counterpart (PrP(Sc)) during prion infection remain undetermined, in part because of a lack of monoclonal antibodies (mAbs) that can distinguish these conformational isoforms. Here we sh...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Kang, Hae-Eun, Bian, Jifeng, Kane, Sarah J., Kim, Sehun, Selwyn, Vanessa, Crowell, Jenna, Bartz, Jason C., Telling, Glenn C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383396/
https://ncbi.nlm.nih.gov/pubmed/32513872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012796
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