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Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

Quinacrine’s ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the production of related...

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Detalhes bibliográficos
Main Authors: Bian, Jifeng, Kang, Hae-Eun, Telling, Glenn C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000840/
https://ncbi.nlm.nih.gov/pubmed/24711410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322377111
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