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Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

Quinacrine’s ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the production of related...

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Detaylı Bibliyografya
Asıl Yazarlar: Bian, Jifeng, Kang, Hae-Eun, Telling, Glenn C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000840/
https://ncbi.nlm.nih.gov/pubmed/24711410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322377111
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