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Quinacrine promotes replication and conformational mutation of chronic wasting disease prions
Quinacrine’s ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the production of related...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4000840/ https://ncbi.nlm.nih.gov/pubmed/24711410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322377111 |
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