Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage

Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Lachmann, Peter, Hickmann, Linda, Steglich, Anne, Al-Mekhlafi, Moath, Gerlach, Michael, Jetschin, Niels, Jahn, Steffen, Hamann, Brigitte, Wnuk, Monika, Madsen, Kirsten, Djonov, Valentin, Chen, Min, Weinstein, Lee S., Hohenstein, Bernd, Hugo, Christian P.M., Todorov, Vladimir T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698073/
https://ncbi.nlm.nih.gov/pubmed/28775003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017020173
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