Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage

Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we...

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Veröffentlicht in:J Am Soc Nephrol
Hauptverfasser: Lachmann, Peter, Hickmann, Linda, Steglich, Anne, Al-Mekhlafi, Moath, Gerlach, Michael, Jetschin, Niels, Jahn, Steffen, Hamann, Brigitte, Wnuk, Monika, Madsen, Kirsten, Djonov, Valentin, Chen, Min, Weinstein, Lee S., Hohenstein, Bernd, Hugo, Christian P.M., Todorov, Vladimir T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2017
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698073/
https://ncbi.nlm.nih.gov/pubmed/28775003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017020173
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