Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage

Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we...

詳細記述

保存先:
書誌詳細
出版年:J Am Soc Nephrol
主要な著者: Lachmann, Peter, Hickmann, Linda, Steglich, Anne, Al-Mekhlafi, Moath, Gerlach, Michael, Jetschin, Niels, Jahn, Steffen, Hamann, Brigitte, Wnuk, Monika, Madsen, Kirsten, Djonov, Valentin, Chen, Min, Weinstein, Lee S., Hohenstein, Bernd, Hugo, Christian P.M., Todorov, Vladimir T.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2017
主題:
Basic Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5698073/
https://ncbi.nlm.nih.gov/pubmed/28775003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017020173
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