Generation and characterization of aptamers targeting factor XIa

BACKGROUND: The plasma protease factor XIa (FXIa) has become a target of interest for therapeutics designed to prevent or treat thrombotic disorders. METHODS: We used a solution-based, directed evolution approach called systematic evolution of ligands by exponential enrichment (SELEX) to isolate RNA...

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Veröffentlicht in:Thromb Res
Hauptverfasser: Woodruff, R. S., Ivanov, I., Verhamme, I.M., Sun, M-f., Gailani, D., Sullenger, B.A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697752/
https://ncbi.nlm.nih.gov/pubmed/28644959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2017.06.015
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