The Mechanism Underlying Activation of Factor IX by Factor XIa

Factor XI (fXI) is the zymogen of a plasma protease, factor XIa (fXIa), that contributes to thrombin generation during blood coagulation by proteolytic conversion of factor IX (fIX) to factor IXaβ (fIXaβ). There is considerable interest in fXIa as a therapeutic target because it contributes to throm...

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Bibliographic Details
Main Authors:	Gailani, David, Geng, Yipeng, Verhamme, Ingrid, Sun, Mao-fu, Bajaj, S. Paul, Messer, Amanda, Emsley, Jonas
Format:	Artigo
Language:	Inglês
Published:	2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4017667/ https://ncbi.nlm.nih.gov/pubmed/24759143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2014.03.020
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The Mechanism Underlying Activation of Factor IX by Factor XIa

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