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Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes

Drug-induced off-target cardiotoxicity, particularly following anti-cancer therapy, is a major concern in new drug discovery and development. To ensure patient safety and efficient pharmaceutical drug development, there is an urgent need to develop more predictive cell model systems and distinct tox...

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Detalhes bibliográficos
Publicado no:Amino Acids
Main Authors: Chaudhari, Umesh, Ellis, James K., Wagh, Vilas, Nemade, Harshal, Hescheler, Jürgen, Keun, Hector C., Sachinidis, Agapios
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696498/
https://ncbi.nlm.nih.gov/pubmed/28421296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-017-2419-0
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