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Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes

Drug-induced off-target cardiotoxicity, particularly following anti-cancer therapy, is a major concern in new drug discovery and development. To ensure patient safety and efficient pharmaceutical drug development, there is an urgent need to develop more predictive cell model systems and distinct tox...

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Bibliografische gegevens
Gepubliceerd in:Amino Acids
Hoofdauteurs: Chaudhari, Umesh, Ellis, James K., Wagh, Vilas, Nemade, Harshal, Hescheler, Jürgen, Keun, Hector C., Sachinidis, Agapios
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Vienna 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696498/
https://ncbi.nlm.nih.gov/pubmed/28421296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-017-2419-0
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