Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity. The purpose of this study was to develop an in vitro repeated exposure toxicity methodology allowing the...

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Bibliographic Details
Published in:Arch Toxicol
Main Authors: Chaudhari, Umesh, Nemade, Harshal, Wagh, Vilas, Gaspar, John Antonydas, Ellis, James K., Srinivasan, Sureshkumar Perumal, Spitkovski, Dimitry, Nguemo, Filomain, Louisse, Jochem, Bremer, Susanne, Hescheler, Jürgen, Keun, Hector C., Hengstler, Jan G., Sachinidis, Agapios
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
Subjects:
In Vitro Systems
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065579/
https://ncbi.nlm.nih.gov/pubmed/26537877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1623-5
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