Structural basis for the assembly of the Ragulator-Rag GTPase complex

The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in regulating cell growth and metabolism by responding to cellular nutrient conditions. The activity of mTORC1 is controlled by Rag GTPases, which are anchored to lysosomes via Ragulator, a pentameric protein complex consist...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Yonehara, Ryo, Nada, Shigeyuki, Nakai, Tomokazu, Nakai, Masahiro, Kitamura, Ayaka, Ogawa, Akira, Nakatsumi, Hirokazu, Nakayama, Keiichi I., Li, Songling, Standley, Daron M., Yamashita, Eiki, Nakagawa, Atsushi, Okada, Masato
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696360/
https://ncbi.nlm.nih.gov/pubmed/29158492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01762-3
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