Acquisition of EGFR TKI resistance and EMT phenotype is linked with activation of IGF1R/NF-κB pathway in EGFR-mutant NSCLC

Epithelial-mesenchymal transition (EMT) is clinically associated with acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in non-small cell lung cancers (NSCLC). However, the mechanisms promoting EMT in EGFR TKI-resistant NSCLC have not been fully elucidat...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Li, Ling, Gu, Xiajing, Yue, Jinnan, Zhao, Qingnan, Lv, Dacheng, Chen, Hongzhuan, Xu, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696177/
https://ncbi.nlm.nih.gov/pubmed/29190911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21170
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