Epigenetic silencing of miR-483-3p promotes acquired gefitinib resistance and EMT in EGFR-mutant NSCLC by targeting integrin β3

All lung cancers patients with epidermal growth factor receptor (EGFR) mutation inevitably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). In up to 30% of cases, the mechanism underlying acquired resistance remains unknown. MicroRNAs (miRNAs) is a group of small non-coding RNAs...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Yue, Jinnan, Lv, Dacheng, Wang, Caiyun, Li, Ling, Zhao, Qingnan, Chen, Hongzhuan, Xu, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072709/
https://ncbi.nlm.nih.gov/pubmed/29717264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0276-2
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